Explain the steps that genetic mutation classifiers use to predict if this mutation is neutral or pathogenic. Example of mutation classifiers are PolyPhen-2, MutationTaster, Mutation Assessor, FATHMM,

Explain the steps that genetic mutation classifiers use to predict if this mutation is neutral or pathogenic. Example of mutation classifiers are PolyPhen-2, MutationTaster, Mutation Assessor, FATHMM, PANTHER, PhD-SNP, SNAP. They explain their way on their published paper but, I don’t understand it very well.